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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		HelqGt(RRF112)Byg
gene trap RRF112, BayGenomics
MGI:4127882
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		HelqGt(RRF112)Byg/HelqGt(RRF112)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:5553174
ht2
 		HelqGt(RRF112)Byg/Helq+ involves: 129P2/OlaHsd * C57BL/6 MGI:5553173


Genotype
MGI:5553174
hm1
Allelic
Composition		 HelqGt(RRF112)Byg/HelqGt(RRF112)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HelqGt(RRF112)Byg mutation (0 available); any Helq mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogonia morphology ( J:206104 )
• reduced c-Kit+ spermatogonia
ovary cyst ( J:206104 )
• cystic hyperplasia
testicular atrophy ( J:206104 )
• varying degree
reduced fertility ( J:206104 )
• females contribute more to reduced fertility than male mice
decreased litter size ( J:206104 )
• mating homozygotes produces fewer and smaller litters than heterozygotes

neoplasm
increased gland tumor incidence ( J:206104 )
• salivary, thyroid, parathyroid, adrenal, mammary and endometrial gland adenomas

endocrine/exocrine glands
ovary cyst ( J:206104 )
• cystic hyperplasia
testicular atrophy ( J:206104 )
• varying degree
increased gland tumor incidence ( J:206104 )
• salivary, thyroid, parathyroid, adrenal, mammary and endometrial gland adenomas

nervous system

integument

growth/size/body
ovary cyst ( J:206104 )
• cystic hyperplasia

cellular
abnormal spermatogonia morphology ( J:206104 )
• reduced c-Kit+ spermatogonia




Genotype
MGI:5553173
ht2
Allelic
Composition		 HelqGt(RRF112)Byg/Helq+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HelqGt(RRF112)Byg mutation (0 available); any Helq mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovary morphology ( J:206104 )
• luteinized stroma in 2 of 7 mice
decreased mature ovarian follicle number ( J:206104 )
• few or no maturing follicles in all mice
absent mature ovarian follicles ( J:206104 )
• few or no maturing follicles in all mice
ovary atrophy ( J:206104 )
• dystrophic/atrophic in 5 of 7 mice
ovary cyst ( J:206104 )
• in 4 of 7 mice

neoplasm
increased intestinal adenoma incidence ( J:206104 )
• gastrointestinal adenomas in 3 of 7 female mice
increased pituitary adenoma incidence ( J:206104 )
• in 5 of 7 female mice

endocrine/exocrine glands
abnormal ovary morphology ( J:206104 )
• luteinized stroma in 2 of 7 mice
decreased mature ovarian follicle number ( J:206104 )
• few or no maturing follicles in all mice
absent mature ovarian follicles ( J:206104 )
• few or no maturing follicles in all mice
ovary atrophy ( J:206104 )
• dystrophic/atrophic in 5 of 7 mice
ovary cyst ( J:206104 )
• in 4 of 7 mice
increased pituitary adenoma incidence ( J:206104 )
• in 5 of 7 female mice

nervous system
increased pituitary adenoma incidence ( J:206104 )
• in 5 of 7 female mice

growth/size/body
ovary cyst ( J:206104 )
• in 4 of 7 mice

digestive/alimentary system
increased intestinal adenoma incidence ( J:206104 )
• gastrointestinal adenomas in 3 of 7 female mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory