All Phenotypes Foxp4<Gt(RRF116)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxp4^{Gt(RRF116)Byg}
gene trap RRF116, BayGenomics
MGI:4127879

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxp4^{Gt(RRF116)Byg}/Foxp4^{Gt(RRF116)Byg}	involves: 129P2/OlaHsd	MGI:5440700
ht2	Foxp4^{Gt(RRF116)Byg}/Foxp4^tm1Eem	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5440702

Allelic Composition	Foxp4^{Gt(RRF116)Byg}/Foxp4^{Gt(RRF116)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4^{Gt(RRF116)Byg} mutation (0 available); any Foxp4 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:188384 )

• fewer than expected mice are present at E11.5 indicating mice begin to die around E10.5

nervous system

abnormal neural tube morphology ( J:188384 )

• in some mice between E10.5 and E13.5

• to a greater extent than in Foxp4^tm1Eem homozygotes

abnormal floor plate morphology ( J:188384 )

• occasionally duplicated

spina bifida ( J:188384 )

holoprosencephaly ( J:188384 )

exencephaly ( J:188384 )

embryo

abnormal neural tube morphology ( J:188384 )

• in some mice between E10.5 and E13.5

• to a greater extent than in Foxp4^tm1Eem homozygotes

abnormal floor plate morphology ( J:188384 )

• occasionally duplicated

spina bifida ( J:188384 )

abnormal notochord morphology ( J:188384 )

• occasionally duplicated

Allelic Composition	Foxp4^{Gt(RRF116)Byg}/Foxp4^tm1Eem
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4^{Gt(RRF116)Byg} mutation (0 available); any Foxp4 mutation (89 available)
Foxp4^tm1Eem mutation (0 available); any Foxp4 mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:188384 )

• authors state that mice exhibit the same neural tube defects as in Foxp4^{Gt(RRF116)Byg} homozygotes at a higher frequency likely due to increased survival

embryo

abnormal neural tube morphology ( J:188384 )

• authors state that mice exhibit the same neural tube defects as in Foxp4^{Gt(RRF116)Byg} homozygotes at a higher frequency likely due to increased survival

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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