Phenotypes associated with this allele

• Allele Symbol: Epcam^{Gt(RST556)Byg}
• Allele Name: gene trap RST556, BayGenomics
• Allele ID: MGI:4127613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epcam^Gt(RST556)Byg/Epcam^Gt(RST556)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4418716

Genotype
MGI:4418716

hm1

• Allelic Composition: Epcam^{Gt(RST556)Byg}/Epcam^{Gt(RST556)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Developmental delay in Epcam^{Gt(RST556)Byg}/Epcam^{Gt(RST556)Byg} embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:155941 )

• become nonviable between E10.5 and E11.5 with none detected after E12.5

embryo

embryonic growth arrest ( J:155941 )

• arrest around E10.5

decreased embryo size ( J:155941 )

• at E9.5 embryos compared to wild-type siblings

abnormal neural tube closure ( J:155941 )

• at E9.5 embryos sometimes exhibit delayed, incomplete neural tube closure

delayed neural tube closure ( J:155941 )

• often delayed by E9.5

decreased trophoblast giant cell number ( J:155941 )

• decrease in the frequency and number of parietal trophoblast giant cells

abnormal placenta labyrinth morphology ( J:155941 )

• thin with limited villous formation

small placenta ( J:155941 )

growth/size/body

decreased embryo size ( J:155941 )

• at E9.5 embryos compared to wild-type siblings

homeostasis/metabolism

abnormal thrombosis ( J:155941 )

• at E9.5, micro-thrombi are observed in surrounding capillaries adjacent to the chorionic plate in some embryos

nervous system

abnormal neural tube closure ( J:155941 )

• at E9.5 embryos sometimes exhibit delayed, incomplete neural tube closure

delayed neural tube closure ( J:155941 )

• often delayed by E9.5