Phenotypes associated with this allele

• Allele Symbol: Faf1^Gt(XK588)Byg
• Allele Name: gene trap XK588, BayGenomics
• Allele ID: MGI:4127400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Faf1^Gt(XK588)Byg/Faf1^Gt(XK588)Byg	B6.129P2-Faf1^Gt(XK588)Byg	MGI:5488758

Genotype
MGI:5488758

hm1

• Allelic Composition: Faf1^Gt(XK588)Byg/Faf1^Gt(XK588)Byg
• Genetic Background: B6.129P2-Faf1^Gt(XK588)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:194987 )

• in MPTP-treated mice to a lesser extent than in similarly treated wild-type mice

cellular

decreased sensitivity to induced cell death ( J:194987 )

• in MPP+ treated mouse embryonic fibroblasts

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:194987 )

• mice are protected from MPTP-induced dopaminergic neuronal degeneration in the substantia nigra pars compacta and reduced impairment of motor coordination compared with wild-type mice

homeostasis/metabolism

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:194987 )

• mice are protected from MPTP-induced dopaminergic neuronal degeneration in the substantia nigra pars compacta and reduced impairment of motor coordination compared with wild-type mice

nervous system

decreased susceptibility to dopaminergic neuron neurotoxicity ( J:194987 )

• mice are protected from MPTP-induced dopaminergic neuronal degeneration in the substantia nigra pars compacta and reduced impairment of motor coordination compared with wild-type mice