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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdlim5Gt(XH199)Byg
gene trap XH199, BayGenomics
MGI:4126899
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdlim5Gt(XH199)Byg/Pdlim5Gt(XH199)Byg B6.129P2-Pdlim5Gt(XH199)Byg MGI:5516493
ht2
 		Pdlim5Gt(XH199)Byg/Pdlim5+ B6.129P2-Pdlim5Gt(XH199)Byg MGI:5516494


Genotype
MGI:5516493
hm1
Allelic
Composition		 Pdlim5Gt(XH199)Byg/Pdlim5Gt(XH199)Byg
Genetic
Background		 B6.129P2-Pdlim5Gt(XH199)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdlim5Gt(XH199)Byg mutation (0 available); any Pdlim5 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:200039 )
• no mice are present at genotyping (no time of death given)




Genotype
MGI:5516494
ht2
Allelic
Composition		 Pdlim5Gt(XH199)Byg/Pdlim5+
Genetic
Background		 B6.129P2-Pdlim5Gt(XH199)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdlim5Gt(XH199)Byg mutation (0 available); any Pdlim5 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:200039 )
N
• untreated mice exhibit normal performance on a rotarod, novelty seeking, social interaction, locomotion and prepulse inhibition
impaired behavioral response to addictive substance ( J:200039 )
• methamphetamine-treated (acute or chronic) mice exhibit reduced enhanced locomotion and impaired prepulse inhibition compared with wild-type mice
behavioral despair ( J:200039 )
• increased immobility in the forced swimming test
• however, treatment with imipramine attenuates immobility time
decreased locomotor activity ( J:200039 )
• methamphetamine-treated (acute or chronic) mice exhibit reduced enhanced locomotion compared with wild-type mice

nervous system
abnormal prepulse inhibition ( J:200039 )
• in methamphetamine-treated (acute or chronic) mice
• however, startle response is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory