Phenotypes associated with this allele

• Allele Symbol: Akap12^Gt(XE450)Byg
• Allele Name: gene trap XE450, BayGenomics
• Allele ID: MGI:4126493
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akap12^Gt(XE450)Byg/Akap12^Gt(XE450)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5561202

Genotype
MGI:5561202

hm1

• Allelic Composition: Akap12^Gt(XE450)Byg/Akap12^Gt(XE450)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:207542 )

• decreased cardiomyocytes intracellular calcium transients in the absence of and following isoproterenol stimulation

abnormal heart septum morphology ( J:207542 )

• increased intraventricular septum in the absence of and following isoproterenol stimulation

abnormal heart left ventricle morphology ( J:207542 )

• left ventricular posterior wall at systole is increased in the absence of and following isoproterenol stimulation

• left ventricular internal dimensions at diastole is decreased

• however, left ventricular internal dimensions at diastole are normal

increased cardiac stroke volume ( J:207542 )

• in the absence of and following isoproterenol stimulation

increased cardiac muscle contractility ( J:207542 )

• increased ejection fraction, left ventricular shortening and fractional shortening in the absence of and following isoproterenol stimulation

abnormal myocardial fiber physiology ( J:207542 )

• increased sarcomere fractional shortening in cardiomyocytes in the absence of and following isoproterenol stimulation

muscle

abnormal myocardial fiber morphology ( J:207542 )

• decreased cardiomyocytes intracellular calcium transients in the absence of and following isoproterenol stimulation

increased cardiac muscle contractility ( J:207542 )

• increased ejection fraction, left ventricular shortening and fractional shortening in the absence of and following isoproterenol stimulation