Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gigyf2Gt(XH076)Byg mutation
(0 available);
any
Gigyf2 mutation
(103 available)
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mortality/aging
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• 25% of mice die within the first day after birth
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• only 15% of expected mice are present at weaning
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growth/size/body
behavior/neurological
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• after birth, mice exhibit a decrease in the size of gastric milk spot compared with wild-type mice
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Allelic
Composition |
Gigyf2Gt(XH076)Byg/Gigyf2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gigyf2Gt(XH076)Byg mutation
(0 available);
any
Gigyf2 mutation
(103 available)
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nervous system
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• at 15 months, mice exhibit a decrease in the neuronal to glial cell ratio compared to in wild-type mice
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• mice exhibit an increase in alpha-synuclein+ neuritic plaques in the cerebrum and spinal cord compared to in wild-type mice
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• in the spinal cord and brain
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• at 15 months, mice exhibit eosinophilic degeneration with nuclear pyknosis, axonal swelling, and rare inclusion body-like structures predominantly in large pyramidal neurons in the ventral horns of the spinal cord unlike wild-type mice
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behavior/neurological
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• at 12 months, 50% of mice exhibit mild truncal and hind limb motor dysfunction with exaggerated splaying of the hind limbs and delayed positional correction when dropped 15 cm on a flat surface compared with wild-type mice
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• at 15 months, mice exhibit a 50% decrease in staying time on a rotarod compared with wild-type mice
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cellular
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• more mouse embryonic fibroblasts treated with etoposide are in S-phase than similarly treated wild-type cells
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Analysis Tools