Phenotypes associated with this allele

• Allele Symbol: Arpc3^Gt(XG476)Byg
• Allele Name: gene trap XG476, BayGenomics
• Allele ID: MGI:4125947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5427568

Genotype
MGI:5427568

hm1

• Allelic Composition: Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Deficient lamellipodia formation in Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg fibroblasts

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:185040 )

• as early as E3.5

cellular

abnormal fibroblast physiology ( J:185040 )

• mouse embryonic fibroblasts exhibit defects in lamellipodia formation compared with wild-type mice

abnormal fibroblast chemotaxis ( J:185040 )

• mouse embryonic fibroblasts exhibit defective chemotaxis response to an EGF gradient compared with wild-type cells

impaired fibroblast cell migration ( J:185040 )

• mouse embryonic fibroblasts exhibit a lack of sustained migration directionality leading to impaired wound healing compared with wild-type cells

homeostasis/metabolism

impaired wound healing ( J:185040 )

• mouse embryonic fibroblasts exhibit a lack of sustained migration directionality leading to impaired wound healing compared with wild-type cells