All Phenotypes Arpc3<Gt(XG476)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Arpc3^Gt(XG476)Byg
gene trap XG476, BayGenomics
MGI:4125947

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5427568

Allelic Composition	Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arpc3^Gt(XG476)Byg mutation (0 available); any Arpc3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Deficient lamellipodia formation in Arpc3^Gt(XG476)Byg/Arpc3^Gt(XG476)Byg fibroblasts

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:185040 )

• as early as E3.5

cellular

abnormal fibroblast physiology ( J:185040 )

• mouse embryonic fibroblasts exhibit defects in lamellipodia formation compared with wild-type mice

abnormal fibroblast chemotaxis ( J:185040 )

• mouse embryonic fibroblasts exhibit defective chemotaxis response to an EGF gradient compared with wild-type cells

impaired fibroblast cell migration ( J:185040 )

• mouse embryonic fibroblasts exhibit a lack of sustained migration directionality leading to impaired wound healing compared with wild-type cells

homeostasis/metabolism

impaired wound healing ( J:185040 )

• mouse embryonic fibroblasts exhibit a lack of sustained migration directionality leading to impaired wound healing compared with wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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