Analysis Tools
mortality/aging
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• mice die around E5 due to a generalized cell proliferation defects
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Allele Symbol Allele Name Allele ID |
Dgcr8Gt(XG058)Byg gene trap XG058, BayGenomics MGI:4125742 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die around E5 due to a generalized cell proliferation defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus
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• distribution is altered at E18.5
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• decrease in volume at P0
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• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal locomotor activity in an open field test
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• male mice exhibit impaired performance in the Morris Water maze compared with wild-type mice
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• male, but not female, mice exhibit reduced spontaneous alternation in a Y-maze compared with wild-type mice
• however, number of arm entries is normal and treatment with IGF2 rescues phenotype
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• male mice exhibit increased immobility in a forced swim test compared with wild-type mice
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• impaired
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| N |
• mice exhibit normal morphological development of the brain
• mice exhibit normal apoptosis in the lateral ventricle and hippocampal dentate gyrus
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• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice
• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell
• however, proliferation in the subventricular zone is normal
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• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice
• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell
• however, proliferation in the subventricular zone is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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