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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ero1aGt(XST171)Byg
gene trap XST171, BayGenomics
MGI:4125474
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ero1aGt(XST171)Byg/Ero1aGt(XST171)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:4398675
cx2
 		Ero1aGt(XST171)Byg/Ero1aGt(XST171)Byg
Ero1bGt(P077G11)Wrst/Ero1bGt(P077G11)Wrst 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4441478


Genotype
MGI:4398675
hm1
Allelic
Composition		 Ero1aGt(XST171)Byg/Ero1aGt(XST171)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ero1aGt(XST171)Byg mutation (0 available); any Ero1a mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:153833 )
• macrophages treated with excess lipoprotein-cholesterol fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type
decreased macrophage apoptosis ( J:153833 )
• under cholesterol loading conditions or after treatment with 7-ketocholesterol, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

cellular
decreased sensitivity to induced cell death ( J:153833 )
• mouse embryonic fibroblasts are protected from apoptosis induced by tunicamycin or azetidine unlike wild-type cells
decreased macrophage apoptosis ( J:153833 )
• under cholesterol loading conditions or after treatment with 7-ketocholesterol, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages

hematopoietic system
abnormal macrophage physiology ( J:153833 )
• macrophages treated with excess lipoprotein-cholesterol fail to exhibit an increase in IP3-induced calcium release unlike similarly wild-type
decreased macrophage apoptosis ( J:153833 )
• under cholesterol loading conditions or after treatment with 7-ketocholesterol, macrophages treated exhibit less apoptosis compared with similarly treated wild-type macrophages




Genotype
MGI:4441478
cx2
Allelic
Composition		 Ero1aGt(XST171)Byg/Ero1aGt(XST171)Byg
Ero1bGt(P077G11)Wrst/Ero1bGt(P077G11)Wrst
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ero1aGt(XST171)Byg mutation (0 available); any Ero1a mutation (28 available)
Ero1bGt(P077G11)Wrst mutation (0 available); any Ero1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:158805 )
• as in Ero1lbGt(P077G11)Wrst homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory