All Phenotypes Glg1<Gt(RST092)Byg> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Glg1^{Gt(RST092)Byg}/Glg1^{Gt(RST092)Byg}
Genetic Background	B6J.129P2-Glg1^{Gt(RST092)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1^{Gt(RST092)Byg} mutation (0 available); any Glg1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:226586 )

• no homozygotes are obtained at E10.5-E15.5 or at weaning

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show significantly decreased numbers of firmly attached leukocytes on endothelial cells in cremaster venules relative to wild-type controls

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

hematopoietic system

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cellular

abnormal cellular extravasation ( J:226586 )

• at 4 days after i.p. thioglycollate injection, 10-wk-old heterozygotes exhibit significantly decreased intraperitoneal leukocytes relative to wild-type controls

abnormal leukocyte adhesion ( J:226586 )

enhanced leukocyte tethering or rolling ( J:226586 )

• following challenge with local TNF injection, 8-wk-old male heterozygotes show increased numbers of rolling leukocytes in cremaster venules relative to wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:226586 )

• heterozygotes are viable and develop normally with no apparent phenotypic abnormalities in the unchallenged state

• at 18 weeks of age, heterozygotes fed a high-fat, high-sucrose diet for 10 weeks display an impaired endothelial-dependent relaxation response to acetylcholine, that is similar in extent to that seen in wild-type controls

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Glg1^{Gt(RST092)Byg}/Glg1⁺
Genetic Background	B6J.129P2-Apoe^tm1Unc Glg1^{Gt(RST092)Byg}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (146 available)
Glg1^{Gt(RST092)Byg} mutation (0 available); any Glg1 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:226586 )

N	• mice exhibit no significant differences in right and left ventricular chamber thickness or in myocardial collagen deposition relative to Apoe^tm1Unc homozygotes

atherosclerotic lesions ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit atherosclerotic lesions with increased collagen deposition and fewer macrophages per mm2 of lesion relative to lesions from Apoe^tm1Unc homozygotes, as shown by collagen-specific (Sirius Red) and macrophage-specific (CD68) staining of aortic valves

• altered lesion composition suggests increased plaque stability; however, no differences in lesion area and thickness or in accumulation of smooth muscle cells are observed relative to Apoe^tm1Unc homozygotes

immune system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

hematopoietic system

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

decreased macrophage cell number ( J:226586 )

• mice exhibit a significantly reduced macrophage content and CD68 expression in liver tissue relative to Apoe^tm1Unc homozygotes

homeostasis/metabolism

increased collagen level ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit significantly increased collagen deposition in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

cellular

impaired macrophage chemotaxis ( J:226586 )

• after 9 weeks on a Western diet, mice exhibit a significantly reduced macrophage content in atherosclerotic lesions relative to Apoe^tm1Unc homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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