Phenotypes associated with this allele

• Allele Symbol: Nln^{Gt(NPX481)Byg}
• Allele Name: gene trap NPX481, BayGenomics
• Allele ID: MGI:4125183
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nln^Gt(NPX481)Byg/Nln^Gt(NPX481)Byg	B6.129P2-Nln^Gt(NPX481)Byg	MGI:5305449

Genotype
MGI:5305449

hm1

• Allelic Composition: Nln^{Gt(NPX481)Byg}/Nln^{Gt(NPX481)Byg}
• Genetic Background: B6.129P2-Nln^{Gt(NPX481)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:214116 )

• slight, but significant 10% decrease in body weight

• however, no difference in the specific mass of the internal organs

homeostasis/metabolism

impaired exercise endurance ( J:214116 )

• in the low intensity running regime until exhaustion, mutants run about 36% less compared to wild-type mice

• however, mutants show similar running to wild-type mice in the high intensity running regime

abnormal gluconeogenesis ( J:214116 )

• liver gluconeogenesis capacity of mutants is higher than in wild-type mice as indicated by the intraperitoneal pyruvate tolerance test in animals fasted for 16 hours

improved glucose tolerance ( J:214116 )

• mice fasted for 12 hours show lower glucose concentrations at 15, 30, 60, and 90 min of the glucose tolerance test compared to wild-type mice

increased insulin sensitivity ( J:214116 )

• mice show an increase in insulin sensitivity in the insulin tolerance test

behavior/neurological

impaired exercise endurance ( J:214116 )

• in the low intensity running regime until exhaustion, mutants run about 36% less compared to wild-type mice

• however, mutants show similar running to wild-type mice in the high intensity running regime

cellular

abnormal cellular respiration ( J:214116 )

• mice show alteration in mRNA expression of genes typical for slow twitch type I fibers, urea cycle, and glycolytic pathway in the gastrocnemius but not the soleus muscle and a decrease of mitochondrial enzyme SDH and Cox staining suggesting reduced mitochondrial oxidative activity

cardiovascular system

cardiovascular system phenotype ( J:214116 )

N • mice show normal blood pressure parameters

reproductive system

reproductive system phenotype ( J:214116 )

N • mice show normal fertility