All Phenotypes Terf2ip<Gt(XD108)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Terf2ip^Gt(XD108)Byg
gene trap XD108, BayGenomics
MGI:4125012

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Terf2ip^Gt(XD108)Byg/Terf2ip^Gt(XD108)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4822388
ht2	Terf2ip^Gt(XD108)Byg/Terf2ip⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4822389

Allelic Composition	Terf2ip^Gt(XD108)Byg/Terf2ip^Gt(XD108)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf2ip^Gt(XD108)Byg mutation (0 available); any Terf2ip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:163158 )

• mice die before E6.5

Allelic Composition	Terf2ip^Gt(XD108)Byg/Terf2ip⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Terf2ip^Gt(XD108)Byg mutation (0 available); any Terf2ip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:163158 )

• LPS-treated mice exhibit reduced activation of NF-kappaB-dependent cytokines and increased survival compared with similarly treated wild-type mice

immune system

decreased susceptibility to endotoxin shock ( J:163158 )

• in LPS-treated mice

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:163158 )

• LPS-treated mice exhibit reduced activation of NF-kappaB-dependent cytokines and increased survival compared with similarly treated wild-type mice

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