All Phenotypes Tnrc6a<Gt(XE786)Byg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tnrc6a^Gt(XE786)Byg
gene trap XE786, BayGenomics
MGI:4124681

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5315770

Allelic Composition	Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnrc6a^Gt(XE786)Byg mutation (0 available); any Tnrc6a mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Embryonic lethality and yolk sac defects in Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:182447 )

• most mice mice die between E9.5 and E12.5

hematopoietic system

impaired hematopoiesis ( J:182447 )

decreased hematopoietic cell number ( J:182447 )

• in the yolk sac

decreased erythrocyte cell number ( J:182447 )

• at E9.5

embryo

abnormal visceral yolk sac blood island morphology ( J:182447 )

• blood islands are smaller with fewer hematopoietic cells compared to in wild-type mice

abnormal extraembryonic endoderm formation ( J:182447 )

• thin endoderm layer in the yolk sac at E9.5

integument

pallor ( J:182447 )

• pale at E9.5

cellular

decreased cell proliferation ( J:182447 )

• in the yolk sac endoderm and mesoderm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24