Analysis Tools
mortality/aging
| N |
• mice exhibit normal early postnatal survival
|
nervous system
| N |
• mice exhibit normal gross nervous system morphology including normal motor neuron numbers
|
|
• the rostral corpus callosum is thinner and, particularly at the medial rise, exhibits areas of patchy and irregular myelination or dysmyelination unlike in wild-type mice
|
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• the internal capsule is less branched and narrower than in wild-type mice
|
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• the cerebellar peduncle exhibits patchy, loose myelination unlike in wild-type mice
|
astrocytosis
(
J:164553
)
|
• spinal cord neuron myelin is thin, wavy, and decompacted compared to in wild-type neurons
• however, white matter tracts of the spinal cord exhibit no obvious dysmyelination
|
|
• spinal cords exhibit perpendicular organization of glial fibers suggesting altered spinal cord development compared to in wild-type mice
|
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• in the spinal cord, rostral corpus callosum, and cerebellar peduncle
|
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• in motor and sensory neurons
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behavior/neurological
|
• mice exhibit lower limb motor defects compared with wild-type mice
|
|
• instable gait with hind limb splaying and a rolling walk
|
growth/size/body
|
• as early as P7
|
immune system
| N |
• mice exhibit normal immune systems
|
