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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nme2Gt(69C10)Cmhd
gene trap 69C10, Centre for Modeling Human Disease
MGI:4122609
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nme2Gt(69C10)Cmhd/Nme2Gt(69C10)Cmhd B6.129-Nme2Gt(69C10)Cmhd MGI:4868386


Genotype
MGI:4868386
hm1
Allelic
Composition		 Nme2Gt(69C10)Cmhd/Nme2Gt(69C10)Cmhd
Genetic
Background		 B6.129-Nme2Gt(69C10)Cmhd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme2Gt(69C10)Cmhd mutation (0 available); any Nme2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:167387 )
N
• mice exhibit normal T cell-dependent antigen response
abnormal CD4-positive, alpha-beta T cell physiology ( J:167387 )
• Th0 cells exhibit impaired KCa3.1 channel activity compared with wild-type mice
• however, Th17 function is normal
abnormal T-helper 1 physiology ( J:167387 )
• Th1 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IFN-gamma, IL2, and TNFalpha) production compared with wild-type mice
abnormal T-helper 2 physiology ( J:167387 )
• Th2 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IL13 and TNFalpha) production compared with wild-type mice
decreased interferon-gamma secretion ( J:167387 )
• in TCR-stimulated Th1 cells
decreased interleukin-13 secretion ( J:167387 )
• in TCR-stimulated Th2 cells
decreased interleukin-2 secretion ( J:167387 )
• in TCR-stimulated Th1 cells
decreased tumor necrosis factor secretion ( J:167387 )
• in TCR-stimulated Th1 and Th2 cells

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:167387 )
• however, Th17 function is normal
• Th0 cells exhibit impaired KCa3.1 channel activity compared with wild-type mice
abnormal T-helper 1 physiology ( J:167387 )
• Th1 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IFN-gamma, IL2, and TNFalpha) production compared with wild-type mice
abnormal T-helper 2 physiology ( J:167387 )
• Th2 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IL13 and TNFalpha) production compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory