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Allele Symbol Allele Name Allele ID |
Aggf1Gt(PT036)Byg gene trap PT036, BayGenomics MGI:4122569 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice older than 40 weeks of age show a slightly increased rate of sudden death events
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• 1/3 of embryos die before birth; 56.1% survive to birth and develop to adulthood
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• yolk sacks have fewer vessels and much less vascular branching
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• well-developed vasculature, particularly in the brain area, is not seen at E10.5 as in wild-type embryos
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• less vessel density in lungs of 40 week or older mice compared to wild-type mice
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• fewer vessels are seen in embryos
• 43.9% of embryos show an abnormal vascular phenotype
• however, hearts appear normal at E14.5 and 8 weeks of age in surviving mice
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• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
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• yolk sacks have fewer vessels and much less vascular branching
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• about 35% of adult mice display hemorrhages in the brain, spleen, and lungs
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• lungs of 40 week or older mice show leakage of blood cells
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• some embryos exhibit severe hemorrhages, especially in the cranial region
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• microvascular endothelial cells (MECs) show decreased capability to form capillary tubes
• wound-healing scratch assays show that migration of MECs is decreased
• reduced capillary tube formation by MECs is rescued by overexpression of constitutively active AKT or treatment with recombinant AGGF1
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• vascular permeability of 50-60 week old mice is 2-fold greater than in wild-type mice
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• wound-healing scratch assays show that migration of MECs is decreased
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• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
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• tumor growth of both B16F10 and B16F0 melanoma cells is inhibited compared to growth in wild-type mice
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• well-developed vasculature, particularly in the brain area, is not seen at E10.5 as in wild-type embryos
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• some embryos exhibit severe hemorrhages, especially in the cranial region
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• less vessel density in lungs of 40 week or older mice compared to wild-type mice
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• lungs of 40 week or older mice show leakage of blood cells
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• wound-healing scratch assays show that migration of MECs is decreased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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