Phenotypes associated with this allele

• Allele Symbol: Gpsm3^{Gt(IST12408A1)Tigm}
• Allele Name: gene trap IST12408A1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4075252
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpsm3^Gt(IST12408A1)Tigm/Gpsm3^Gt(IST12408A1)Tigm	involves: C57BL/6N	MGI:5477905

Genotype
MGI:5477905

hm1

• Allelic Composition: Gpsm3^{Gt(IST12408A1)Tigm}/Gpsm3^{Gt(IST12408A1)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased monocyte cell number ( J:193270 )

• decrease in the number of inflammatory monocytes (Ly6C high CD11b+) in the population of isolated splenocytes

abnormal leukocyte physiology ( J:193270 )

• monocytes are more sensitive to apoptotic stimuli induced cell death

abnormal leukocyte migration ( J:193270 )

• Ly6C-enriched/CD11b+ splenocytes have significantly reduced chemotaxis toward CCL2/MCP-1, CX3CL1/FKN, and chemerin

decreased susceptibility to induced arthritis ( J:193270 )

• significant decrease in the severity and incidence of collagen antibody-induced arthritis

skeleton

decreased susceptibility to induced arthritis ( J:193270 )

• significant decrease in the severity and incidence of collagen antibody-induced arthritis

cellular

abnormal leukocyte migration ( J:193270 )

• Ly6C-enriched/CD11b+ splenocytes have significantly reduced chemotaxis toward CCL2/MCP-1, CX3CL1/FKN, and chemerin

hematopoietic system

decreased monocyte cell number ( J:193270 )

• decrease in the number of inflammatory monocytes (Ly6C high CD11b+) in the population of isolated splenocytes

abnormal leukocyte physiology ( J:193270 )

• monocytes are more sensitive to apoptotic stimuli induced cell death

abnormal leukocyte migration ( J:193270 )

• Ly6C-enriched/CD11b+ splenocytes have significantly reduced chemotaxis toward CCL2/MCP-1, CX3CL1/FKN, and chemerin