Phenotypes associated with this allele

• Allele Symbol: Rnd3^{Gt(IST12405G10)Tigm}
• Allele Name: gene trap IST12405G10, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4072882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnd3^Gt(IST12405G10)Tigm/Rnd3^Gt(IST12405G10)Tigm	involves: C57BL/6N	MGI:5517786

Genotype
MGI:5517786

hm1

• Allelic Composition: Rnd3^{Gt(IST12405G10)Tigm}/Rnd3^{Gt(IST12405G10)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

domed cranium ( J:197325 )

• dome shaped skull

nervous system

abnormal brain ventricular system morphology ( J:197325 )

hydrocephaly ( J:197325 )

• brain contains considerable cerebrospinal fluid

• injection of "compound E" in pregnant E12.5 pregnant female mice to inhibit Notch signaling abolishes hydrocephalus

cerebral aqueductal stenosis ( J:197325 )

abnormal brain ependyma morphology ( J:197325 )

• multiple layers of ependymal cells resulting in aqueduct stenosis

enlarged lateral ventricles ( J:197325 )

• extremely enlarged

• thinning of the occipital cortex

dilated third ventricle ( J:197325 )

• extremely dilated or broken

abnormal cerebral aqueduct morphology ( J:197325 )

• narrow or disconnected aqueduct

skeleton

domed cranium ( J:197325 )

• dome shaped skull