Analysis Tools|
Allele Symbol Allele Name Allele ID |
Poldip2Gt(IST12080D9)Tigm gene trap IST12080D9, Texas A&M Institute for Genomic Medicine MGI:4044390 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• fewer than expected mice are present at genotyping
|
|
• in surviving mice with later weaning
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased stiffness in maximally dilated aortic ring
|
|
• fragmented and irregular in thickness and orientation of the elastic lamellae with increased in interlamellar area occupied by fibrillar or amorphous extracellular matric
|
|
• slight reduction in angiotensin II-induced hypertension
|
|
• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not
• however, sensitivity to phenylephrine is normal
|
|
• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice
|
|
• decreased NADPH-dependent production of O2- and hydrogen peroxide
|
|
• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not
• however, sensitivity to phenylephrine is normal
|
|
• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
