All Phenotypes Prss8<Gt(IST10122F12)Tigm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prss8^{Gt(IST10122F12)Tigm}
gene trap IST10122F12, Texas A&M Institute for Genomic Medicine
MGI:3930527

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prss8^{Gt(IST10122F12)Tigm}/Prss8^{Gt(IST10122F12)Tigm}	involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N	MGI:5440261
ht2	Prss8^tm1.1Bug/Prss8^{Gt(IST10122F12)Tigm}	involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N	MGI:5588585

Allelic Composition	Prss8^{Gt(IST10122F12)Tigm}/Prss8^{Gt(IST10122F12)Tigm}
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^{Gt(IST10122F12)Tigm} mutation (0 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:188121 )

• mice die within 48 hours after birth

homeostasis/metabolism

dehydration ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

impaired skin barrier function ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

integument

impaired skin barrier function ( J:188121 )

• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

abnormal epidermis stratum corneum morphology ( J:188121 )

• stratum corneum is completely compacted, presenting with few intercorneocyte lacunae

• 18% reduction in the thickness of the stratum corneum

Allelic Composition	Prss8^tm1.1Bug/Prss8^{Gt(IST10122F12)Tigm}
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8^{Gt(IST10122F12)Tigm} mutation (0 available); any Prss8 mutation (24 available)
Prss8^tm1.1Bug mutation (0 available); any Prss8 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:214122 )

• 73% of mice survive the preweaning period

postnatal lethality, incomplete penetrance ( J:214122 )

• mice are born at the expected ratios and 73% survive the preweaning period

homeostasis/metabolism

impaired skin barrier function ( J:214122 )

• transepidermal water loss is marginally increased relative to wild-type mice

integument

impaired skin barrier function ( J:214122 )

• transepidermal water loss is marginally increased relative to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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