Phenotypes associated with this allele

• Allele Symbol: Mbd5^{Gt(Ayu21-B205)Imeg}
• Allele Name: gene trap Ayu21-B205, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3923358
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd5^Gt(Ayu21-B205)Imeg/Mbd5^Gt(Ayu21-B205)Imeg	B6.Cg-Mbd5^Gt(Ayu21-B205)Imeg	MGI:5617467
ht2	Mbd5^Gt(Ayu21-B205)Imeg/Mbd5^+	B6.Cg-Mbd5^Gt(Ayu21-B205)Imeg	MGI:5617468

Genotype
MGI:5617467

hm1

• Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5^{Gt(Ayu21-B205)Imeg}
• Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:212073 )

• most homozygotes die perinatally 0.7% survival

• single survivor lived 20 days in poor condition before euthanization

Genotype
MGI:5617468

ht2

• Allelic Composition: Mbd5^{Gt(Ayu21-B205)Imeg}/Mbd5⁺
• Genetic Background: B6.Cg-Mbd5^{Gt(Ayu21-B205)Imeg}

integument

integument phenotype ( J:212073 )

N • normal coat and whiskers

growth/size/body

abnormal nasal bone morphology ( J:212073 )

• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

decreased body size ( J:212073 )

• throughout life

decreased body weight ( J:212073 )

• significantly reduced body weight largely due to reduced abdominal fat

adipose tissue

decreased abdominal adipose tissue amount ( J:212073 )

craniofacial

abnormal nasal bone morphology ( J:212073 )

• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

behavior/neurological

behavior/neurological phenotype ( J:212073 )

♂N • behavior testing was all done using male mice on a C57BL/6 background

♂N • normal reflexes

♂N • normal activity in an open field test

abnormal learning/memory/conditioning ( J:212073 )

♂ • impaired learning in both context and cue-based tests

abnormal response to novel object ( J:212073 )

♂ • increased time spent interacting with a novel inanimate object leading to more normal gooming levels

increased grooming behavior ( J:212073 )

♂ • when alone

abnormal motor capabilities/coordination/movement ( J:212073 )

♂

impaired coordination ( J:212073 )

♂ • poorer coordination displayed on a rotarod test and walking on a horizontal wooden dowel

decreased grip strength ( J:212073 )

♂ • reduced grip strength displayed by poorer performance in a hanging wire test

abnormal social investigation ( J:212073 )

♂ • increased levels of interaction with a strange mouse

nervous system

abnormal neurite morphology ( J:212073 )

• significantly reduced neurite length relative to controls after six hours of neuron culture

skeleton

abnormal nasal bone morphology ( J:212073 )

• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

respiratory system

abnormal nasal bone morphology ( J:212073 )

• 60% of mice with craniofacial abnormalities due to abnormal nasal bones

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant intellectual developmental disorder		DOID:0060307	OMIM:PS156200	J:212073