Phenotypes associated with this allele

• Allele Symbol: Trap1^{Gt(E150H04)Wrst}
• Allele Name: gene trap E150H04, German Gene Trap Consortium
• Allele ID: MGI:3916086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trap1^Gt(E150H04)Wrst/Trap1^Gt(E150H04)Wrst	involves: 129P2/OlaHsd * C57BL/6	MGI:5752813

Genotype
MGI:5752813

hm1

• Allelic Composition: Trap1^{Gt(E150H04)Wrst}/Trap1^{Gt(E150H04)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

spleen hyperplasia ( J:226880 )

• at 15 months

decreased inflammatory response ( J:226880 )

• decreased chronic inflammation in the lung, stomach, pancreas and small intestine compared with wild-type mice

cellular

decreased fibroblast proliferation ( J:226880 )

• in mouse embryonic fibroblasts

abnormal oxidative phosphorylation ( J:226880 )

• deregulated mitochondrial respiration with increased oxygen consumption

oxidative stress ( J:226880 )

• increased production of reactive oxygen species in mouse embryonic fibroblasts

homeostasis/metabolism

decreased circulating creatinine level ( J:226880 )

decreased circulating glucose level ( J:226880 )

liver/biliary system

abnormal liver morphology ( J:226880 )

• lower hepatic lipidosis

liver hyperplasia ( J:226880 )

• at 15 months

growth/size/body

decreased body weight ( J:226880 )

• at 15 months

liver hyperplasia ( J:226880 )

• at 15 months

spleen hyperplasia ( J:226880 )

• at 15 months

neoplasm

decreased tumor incidence ( J:226880 )

• no tumors are detected in 15 month old mice compared with 2 out of 3 wild-type mice

endocrine/exocrine glands

abnormal pancreas morphology ( J:226880 )

• reduced pancreatic fibrotic degeneration

hematopoietic system

spleen hyperplasia ( J:226880 )

• at 15 months