All Phenotypes Pcbp4<Gt(D136D11)Wrst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pcbp4^{Gt(D136D11)Wrst}
gene trap D136D11, German Gene Trap Consortium
MGI:3891773

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pcbp4^{Gt(D136D11)Wrst}/Pcbp4^{Gt(D136D11)Wrst}	involves: 129S2/SvPas * C57BL/6	MGI:5925309
ht2	Pcbp4^{Gt(D136D11)Wrst}/Pcbp4⁺	involves: 129S2/SvPas * C57BL/6	MGI:5925310

Allelic Composition	Pcbp4^{Gt(D136D11)Wrst}/Pcbp4^{Gt(D136D11)Wrst}
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcbp4^{Gt(D136D11)Wrst} mutation (0 available); any Pcbp4 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:231514 )

• associated with visceral organs such as the spleen, liver, kidney, and lungs

increased lung adenocarcinoma incidence ( J:231514 )

• papillary predominant lung adenocarcinoma in some mice

increased kidney tumor incidence ( J:231514 )

• in one mouse

cellular

increased fibroblast proliferation ( J:231514 )

• in mouse embryonic fibroblasts

delayed cellular replicative senescence ( J:231514 )

• in mouse embryonic fibroblasts

growth/size/body

decreased body size ( J:231514 )

• female and male mice at P15

decreased body weight ( J:231514 )

• female and male mice

renal/urinary system

increased kidney tumor incidence ( J:231514 )

• in one mouse

respiratory system

increased lung adenocarcinoma incidence ( J:231514 )

• papillary predominant lung adenocarcinoma in some mice

Allelic Composition	Pcbp4^{Gt(D136D11)Wrst}/Pcbp4⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcbp4^{Gt(D136D11)Wrst} mutation (0 available); any Pcbp4 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:231514 )

• associated with visceral organs such as the spleen, liver, kidney, and lungs

increased lung adenocarcinoma incidence ( J:231514 )

• papillary predominant lung adenocarcinoma in some mice

increased kidney tumor incidence ( J:231514 )

• in one mouse

growth/size/body

decreased body weight ( J:231514 )

• female and male

renal/urinary system

increased kidney tumor incidence ( J:231514 )

• in one mouse

respiratory system

increased lung adenocarcinoma incidence ( J:231514 )

• papillary predominant lung adenocarcinoma in some mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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