Phenotypes associated with this allele

• Allele Symbol: Tmem64^{Gt(SYA242)Byg}
• Allele Name: gene trap SYA242, BayGenomics
• Allele ID: MGI:3880885
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem64^Gt(SYA242)Byg/Tmem64^Gt(SYA242)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:5502162

Genotype
MGI:5502162

hm1

• Allelic Composition: Tmem64^{Gt(SYA242)Byg}/Tmem64^{Gt(SYA242)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal bone structure ( J:198051 )

abnormal osteoclast differentiation ( J:198051 )

• reduced with enhanced calcium oscillation and reactive oxygen species production

• however, expression of Tmem64 or Fos restores osteoclast differentiation

decreased osteoclast cell number ( J:198051 )

• with decreased osteoclast surface size

increased bone mineral content ( J:198051 )

increased bone mineral density ( J:198051 )

abnormal osteoblast morphology ( J:198051 )

• increase in osteoblast surface area

enhanced osteoblast differentiation ( J:198051 )

abnormal trabecular bone morphology ( J:198051 )

• increased trabecular bone surface

increased trabecular bone volume ( J:198051 )

• at 6 weeks

abnormal bone trabecula morphology ( J:198051 )

• decreased trabecular spacing

increased bone trabecula number ( J:198051 )

increased trabecular bone thickness ( J:198051 )

increased bone mass ( J:198051 )

increased bone ossification ( J:198051 )

decreased bone resorption ( J:198051 )

homeostasis/metabolism

increased circulating osteocalcin level ( J:198051 )

cellular

enhanced osteoblast differentiation ( J:198051 )

abnormal osteoclast differentiation ( J:198051 )

• reduced with enhanced calcium oscillation and reactive oxygen species production

• however, expression of Tmem64 or Fos restores osteoclast differentiation

hematopoietic system

abnormal osteoclast differentiation ( J:198051 )

• reduced with enhanced calcium oscillation and reactive oxygen species production

• however, expression of Tmem64 or Fos restores osteoclast differentiation

decreased osteoclast cell number ( J:198051 )

• with decreased osteoclast surface size

immune system

abnormal osteoclast differentiation ( J:198051 )

• reduced with enhanced calcium oscillation and reactive oxygen species production

• however, expression of Tmem64 or Fos restores osteoclast differentiation

decreased osteoclast cell number ( J:198051 )

• with decreased osteoclast surface size