All Phenotypes Mcm6<Gt(YHD248)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcm6^{Gt(YHD248)Byg}
gene trap YHD248, BayGenomics
MGI:3878139

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm6^{Gt(YHD248)Byg}/Mcm6^{Gt(YHD248)Byg}	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838133
ht2	Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838132
cx3	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838123
cx4	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838124
cx5	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838125
cx6	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838126
cx7	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838127
cx8	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838137
cx9	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838114
cx10	Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838116

Allelic Composition	Mcm6^{Gt(YHD248)Byg}/Mcm6^{Gt(YHD248)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165667 )

• no viable mice are present at birth

Allelic Composition	Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (49 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (49 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (49 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (49 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• mortality observed in Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ mice is partially rescued

neoplasm

increased tumor incidence ( J:165667 )

• tumor latency is shorted than in Mcm4^chaos3 homozygotes

increased lymphoma incidence ( J:165667 )

Allelic Composition	Mcm4^chaos3/Mcm4^chaos3 Mcm6^{Gt(YHD248)Byg}/Mcm6⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• fewer than expected mice are produced

prenatal lethality, incomplete penetrance ( J:165667 )

• only 10% of expected mice survive to birth

growth/size/body

decreased body weight ( J:165667 )

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