Phenotypes associated with this allele

• Allele Symbol: Ppp2r5e^{Gt(YHD256)Byg}
• Allele Name: gene trap YHD256, BayGenomics
• Allele ID: MGI:3878135
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp2r5e^Gt(YHD256)Byg/Ppp2r5e^Gt(YHD256)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:8169081
cx2	Ppp2r5c^Gt(XP0444)Wtsi/Ppp2r5c^Gt(XP0444)Wtsi Ppp2r5e^Gt(YHD256)Byg/Ppp2r5e^Gt(YHD256)Byg	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:8169088
cx3	Ppp2r5c^Gt(XP0444)Wtsi/Ppp2r5c^+ Ppp2r5e^Gt(YHD256)Byg/Ppp2r5e^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:8169094
cx4	Ppp2r5c^Gt(XP0444)Wtsi/Ppp2r5c^+ Ppp2r5e^Gt(YHD256)Byg/Ppp2r5e^Gt(YHD256)Byg	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:8169095

Genotype
MGI:8169081

hm1

• Allelic Composition: Ppp2r5e^{Gt(YHD256)Byg}/Ppp2r5e^{Gt(YHD256)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:348684 )

• mice exhibit delayed neonatal growth, similar to mice homozygous for either the Ppp2r5e^em1Bmc allele or the Ppp2r5e^em2Bmc allele

Genotype
MGI:8169088

cx2

• Allelic Composition: Ppp2r5c^{Gt(XP0444)Wtsi}/Ppp2r5c^{Gt(XP0444)Wtsi}; Ppp2r5e^{Gt(YHD256)Byg}/Ppp2r5e^{Gt(YHD256)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:348684 )

• although double homozygotes are viable throughout gestation and are born in expected Mendelian ratios, they fail to survive to weaning age

cardiovascular system

abnormal heart development ( J:348684 )

• at E17, fetuses show additive effects on heart development relative to single Ppp2r5c^{Gt(XP0444)Wtsi} homozygotes

ventricular septal defect ( J:348684 )

• at E17, double homozygotes exhibit ventricular septal defects similar to those detected in single Ppp2r5c^{Gt(XP0444)Wtsi} homozygotes

abnormal heart right ventricle morphology ( J:348684 )

• at E17, the right ventricle is underdeveloped and triangular shaped, suggesting that heart abnormalities are slightly more pronounced than those detected in single Ppp2r5c^{Gt(XP0444)Wtsi} homozygotes

Genotype
MGI:8169094

cx3

• Allelic Composition: Ppp2r5c^{Gt(XP0444)Wtsi}/Ppp2r5c⁺; Ppp2r5e^{Gt(YHD256)Byg}/Ppp2r5e⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

cardiovascular system

cardiovascular system phenotype ( J:348684 )

N • at E17, double heterozygotes exhibit no septation defects and have a more fully formed right ventricle than double homozygotes

Genotype
MGI:8169095

cx4

• Allelic Composition: Ppp2r5c^{Gt(XP0444)Wtsi}/Ppp2r5c⁺; Ppp2r5e^{Gt(YHD256)Byg}/Ppp2r5e^{Gt(YHD256)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

cardiovascular system

cardiovascular system phenotype ( J:348684 )

N • at E17, mice exhibit no septation defects and have a more fully formed right ventricle than double homozygotes