Phenotypes associated with this allele

• Allele Symbol: Brk1^{Gt(DC0002)Wtsi}
• Allele Name: gene trap DC0002, Wellcome Trust Sanger Institute
• Allele ID: MGI:3872157
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brk1^Gt(DC0002)Wtsi/Brk1^Gt(DC0002)Wtsi	involves: 129P2/OlaHsd	MGI:4840234

Genotype
MGI:4840234

hm1

• Allelic Composition: Brk1^{Gt(DC0002)Wtsi}/Brk1^{Gt(DC0002)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:166082 )

embryo

failure of blastocyst to hatch from the zona pellucida ( J:166082 )

• cultured embryos fail to hatch by E4.5 and remain as degenerated blastocysts

embryonic growth retardation ( J:166082 )

• embryos that do implant are underdeveloped

disorganized embryonic tissue ( J:166082 )

• embryos that do implant are underdeveloped with disorganized cells and diffuse actin distribution

abnormal blastocyst morphology ( J:166082 )

• cultured embryos fail to hatch by E4.5 and remain as degenerated blastocysts

cellular

abnormal actin cytoskeleton morphology ( J:166082 )

• embryos show an abnormal actin network with absence of proper actin fibers at the apical and basolateral boundary

growth/size/body

embryonic growth retardation ( J:166082 )

• embryos that do implant are underdeveloped

reproductive system

failure of embryo implantation ( J:166082 )

♀ • most embryos fail to implant