Phenotypes associated with this allele

• Allele Symbol: Nono^{Gt(YHA266)Byg}
• Allele Name: gene trap YHA266, BayGenomics
• Allele ID: MGI:3866756
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Nono^Gt(YHA266)Byg/Y	involves: 129P2/OlaHsd	MGI:6469924
ot2	Nono^Gt(YHA266)Byg/Y	involves: 129P2/OlaHsd * C57BL/6J	MGI:5446136

Genotype
MGI:6469924

ot1

• Allelic Composition: Nono^{Gt(YHA266)Byg}/Y
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:294120 )

♂N • normal blood pressure

♂N • normal ventricle size and non-compacted ventricular myocardium

♂N • normal heart to body weight ratio

♂N • normal left ventricular ejection fraction (LVEF), fractional shortening (FS) and left ventricular posterior wall thickness (LVPWd)

small heart ( J:294120 )

♂ • at age 16 weeks

decreased heart weight ( J:294120 )

♂ • at age 16 weeks

cardiac interstitial fibrosis ( J:294120 )

♂ • increased extra-cellular matrix (ECM) with more collagen I and III

decreased left ventricle diastolic pressure ( J:294120 )

♂ • decreased left ventricular end diastolic diameter (LVEDd)

mortality/aging

decreased survivor rate ( J:294120 )

♂ • significantly increased mortality rate up to age 1 year

preweaning lethality, incomplete penetrance ( J:294120 )

♂ • male mice born much below expected Mendelian ratio

growth/size/body

decreased body weight ( J:294120 )

♂ • at age 4 months; reduction larger in males than females

craniofacial

abnormal craniofacial morphology ( J:294120 )

♂

cellular

cardiac interstitial fibrosis ( J:294120 )

♂ • increased extra-cellular matrix (ECM) with more collagen I and III

decreased fibroblast cell migration ( J:294120 )

♂ • reduced cardiac fibroblast migration

increased fibroblast proliferation ( J:294120 )

♂ • increased cardiac fibroblast proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:294120 )

♂N • normal fasting glucose, total cholesterol, triglyceride, LDL and HDL levels

♂N • normal ventricle size and non-compacted ventricular myocardium

♂N • normal heart to body weight ratio

♂N • normal left ventricular ejection fraction (LVEF), fractional shortening (FS) and left ventricular posterior wall thickness (LVPWd)

liver/biliary system

decreased liver weight ( J:294120 )

♂

behavior/neurological

behavior/neurological phenotype ( J:294120 )

♂N • normal food intake

renal/urinary system

decreased kidney weight ( J:294120 )

♂ • right kidney

Genotype
MGI:5446136

ot2

• Allelic Composition: Nono^{Gt(YHA266)Byg}/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

cellular

abnormal cell cycle ( J:193286 )

♂ • 2-fold increase of primary fibroblasts in S phase

♂ • loss of circadian regulation of cell division in primary fibroblasts

increased fibroblast proliferation ( J:193286 )

♂ • marked increased rate of population doubling of primary fibroblasts

delayed cellular replicative senescence ( J:193286 )

♂ • in primary fibroblasts

behavior/neurological

shortened circadian behavior period ( J:189236 , J:193286 )

♂ • decreased by 20 minutes compared to controls under constant dark conditions (J:189236)

♂ • slight (J:193286)

liver/biliary system

abnormal liver physiology ( J:193286 )

♂ • loss of circadian regulation of some genes in the liver

homeostasis/metabolism

impaired wound healing ( J:193286 )

♂ • following a full-thickness incisional wound, immature granulation tissue is characterized by continued fibroblast proliferation, occupying most of the wound area

♂ • collagen secretion is dramatically reduced

♂ • dividing cells form only an immature dysfunctional epidermal layer resting on a disorganized granulation tissue that prevents healing