Phenotypes associated with this allele

• Allele Symbol: Trim27^{Gt(XP0484)Wtsi}
• Allele Name: gene trap XP0484, Wellcome Trust Sanger Institute
• Allele ID: MGI:3858633
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim27^Gt(XP0484)Wtsi/Trim27^Gt(XP0484)Wtsi	B6.129P2-Trim27^Gt(XP0484)Wtsi	MGI:5446917
cx2	Tg(KRT14-Esr1/HRAS)1Pkha/0 Trim27^Gt(XP0484)Wtsi/Trim27^Gt(XP0484)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5446918
cx3	Rb1^tm1Tyj/Rb1^tm1Tyj Trim27^Gt(XP0484)Wtsi/Trim27^Gt(XP0484)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5446919
cx4	Rb1^tm1Tyj/Rb1^+ Trim27^Gt(XP0484)Wtsi/Trim27^Gt(XP0484)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5446920

Genotype
MGI:5446917

hm1

• Allelic Composition: Trim27^{Gt(XP0484)Wtsi}/Trim27^{Gt(XP0484)Wtsi}
• Genetic Background: B6.129P2-Trim27^{Gt(XP0484)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:189317 )

• DMBA/TPA-treated mice develop fewer and smaller tumors compared with wild-type mice

decreased tumor growth/size ( J:189317 )

• smaller tumors in DMBA/TPA-treated mice compared with wild-type mice

cellular

early cellular replicative senescence ( J:189317 )

• in mouse embryonic fibroblasts subjected to a 3T3 protocol

• in tumor cells

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:189317 )

• DMBA/TPA-treated mice develop fewer and smaller tumors compared with wild-type mice

Genotype
MGI:5446918

cx2

• Allelic Composition: Tg(KRT14-Esr1/HRAS)1Pkha/0; Trim27^{Gt(XP0484)Wtsi}/Trim27^{Gt(XP0484)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cellular

early cellular replicative senescence ( J:189317 )

• in mouse embryonic fibroblasts

Genotype
MGI:5446919

cx3

• Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj; Trim27^{Gt(XP0484)Wtsi}/Trim27^{Gt(XP0484)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cellular

increased cell proliferation ( J:189317 )

• under a 3T3 protocol, mouse embryonic fibroblasts exhibit increased cell proliferation compared with cells from Trim27^{Gt(XP0484)Wtsi} homozygotes

Genotype
MGI:5446920

cx4

• Allelic Composition: Rb1^tm1Tyj/Rb1⁺; Trim27^{Gt(XP0484)Wtsi}/Trim27^{Gt(XP0484)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes

increased pituitary gland tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes

increased thyroid tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes

increased thyroid tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes

nervous system

increased pituitary gland tumor incidence ( J:189317 )

• as in Rb1^tm1Tyj heterozygotes