Phenotypes associated with this allele

• Allele Symbol: Ranbp10^{Gt(RRZ226)Byg}
• Allele Name: gene trap RRZ226, BayGenomics
• Allele ID: MGI:3852712
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ranbp10^Gt(RRZ226)Byg/Ranbp10^Gt(RRZ226)Byg	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:5468023

Genotype
MGI:5468023

hm1

• Allelic Composition: Ranbp10^{Gt(RRZ226)Byg}/Ranbp10^{Gt(RRZ226)Byg}
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:193236 )

N • platelets exhibit normal granule numbers

abnormal megakaryocyte differentiation ( J:193236 )

• mice exhibit reduced proplatelet-forming megakaryocytes compared with wild-type mice

• however, peripheral platelet counts are normal

decreased erythrocyte cell number ( J:193236 )

• slightly

increased mean corpuscular volume ( J:193236 )

• slightly

abnormal platelet shape ( J:193236 )

• platelets exhibit less of a discoid shape compared with wild-type cells

decreased platelet aggregation ( J:193236 )

• especially with low concentrations of collagen or thrombin

• however, platelets exhibit normal aggregation response to exogenous ADP or high concentrations of thrombin or collagen

abnormal platelet dense granule physiology ( J:193236 )

• after exposure to PAR4p, platelets fail to release dense granules unlike wild-type cells

• collagen-exposed platelets exhibit a slight reduction in release of dense granules compared with wild-type cells

homeostasis/metabolism

decreased platelet aggregation ( J:193236 )

• especially with low concentrations of collagen or thrombin

• however, platelets exhibit normal aggregation response to exogenous ADP or high concentrations of thrombin or collagen

abnormal platelet dense granule physiology ( J:193236 )

• after exposure to PAR4p, platelets fail to release dense granules unlike wild-type cells

• collagen-exposed platelets exhibit a slight reduction in release of dense granules compared with wild-type cells

increased bleeding time ( J:193236 )

• no stable plug formation in 8 of 10 mice compared with 2 of 10 wild-type mice

cellular

abnormal megakaryocyte differentiation ( J:193236 )

• mice exhibit reduced proplatelet-forming megakaryocytes compared with wild-type mice

• however, peripheral platelet counts are normal