Phenotypes associated with this allele

• Allele Symbol: Syna^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:3852417
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syna^tm1.1Ics/Syna^tm1.1Ics	involves: 129S2/SvPas	MGI:5308866
hm2	Syna^tm1.1Ics/Syna^tm1.1Ics	involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:3852436
cx3	Syna^tm1.1Ics/Syna^tm1.1Ics Synb^tm1.2Ics/Synb^tm1.2Ics	involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6	MGI:5308865

Genotype
MGI:5308866

hm1

• Allelic Composition: Syna^tm1.1Ics/Syna^tm1.1Ics
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:180242 )

• all mice die by E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:180242 )

• fewer than expected mice are present at E12.5 and E13.5

embryo

abnormal placenta labyrinth morphology ( J:180242 )

• fetal vessel space is reduced due to accumulation of labyrinth cells

Genotype
MGI:3852436

hm2

• Allelic Composition: Syna^tm1.1Ics/Syna^tm1.1Ics
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

Growth retardation and decreased vascularization of E13.5 Syna^tm1.1Ics/Syna^tm1.1Ics embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:150813 )

• 20% of mice are dead by E11.5

• 29% of mice are dead by E12.5

• 48% of mice are dead by E13.5

• all mice are dead by E14.5

embryo

abnormal vitelline vasculature morphology ( J:150813 )

• mice exhibit decreased vascularization of the extraembryonic annexes compared with wild-type mice

• unlike in wild-type mice, blood vessel branching at the surface of the yolk sac and on the fetal side of the placenta is barely visible

• fetal blood vessel spaces are reduced compared to in wild-type mice

• fetal blood vessels are likely secondarily compressed by trophoblast cells

embryonic growth retardation ( J:150813 )

• between E11.5 and E13.5

decreased embryo weight ( J:150813 )

• up to 25%

increased trophoblast giant cell number ( J:150813 )

• 1.3-fold

abnormal placenta labyrinth morphology ( J:150813 )

• the labyrinth is more compact than in wild-type mice with clusters of densely packed trophoblast cells

• syncytiotrophoblast formation is impaired compared to in wild-type mice

• the first interhemal syncytial layer is irregular and fails to fuse with trophoblast cells unlike in wild-type mice

• apoptotic cells are detected within the placental labyrinth unlike in wild-type mice

abnormal placental transport ( J:150813 )

• placental transport capacity is reduced compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:150813 )

• between E11.5 and E13.5

decreased embryo weight ( J:150813 )

• up to 25%

cardiovascular system

abnormal vitelline vasculature morphology ( J:150813 )

• mice exhibit decreased vascularization of the extraembryonic annexes compared with wild-type mice

• unlike in wild-type mice, blood vessel branching at the surface of the yolk sac and on the fetal side of the placenta is barely visible

• fetal blood vessel spaces are reduced compared to in wild-type mice

• fetal blood vessels are likely secondarily compressed by trophoblast cells

integument

pallor ( J:150813 )

• embryos are pale

Genotype
MGI:5308865

cx3

• Allelic Composition: Syna^tm1.1Ics/Syna^tm1.1Ics; Synb^tm1.2Ics/Synb^tm1.2Ics
• Genetic Background: involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:180242 )

• mice die between E9.5 and E10.5