Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Mef2c)2Jmol
• Allele Name: transgene insertion 2, Jeffery D Molkentin
• Allele ID: MGI:3851582
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Myh6-Mef2c)2Jmol/0 Tg(Myh6-Ppp3ca)37Eno/0	involves: FVB	MGI:3851788
tg2	Tg(Myh6-Mef2c)2Jmol/0	involves: FVB	MGI:3851787

Genotype
MGI:3851788

cx1

• Allelic Composition: Tg(Myh6-Mef2c)2Jmol/0; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart atrium morphology ( J:111573 )

• mice show large atrial clots

cardiac hypertrophy ( J:111573 )

• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-Mef2c)2Jmol single transgenic animals

decreased cardiac muscle contractility ( J:111573 )

• degree of functional decompensation is not enhanced compared to Tg(Myh6-Mef2c)2Jmol single transgenic mice

muscle

decreased cardiac muscle contractility ( J:111573 )

• degree of functional decompensation is not enhanced compared to Tg(Myh6-Mef2c)2Jmol single transgenic mice

growth/size/body

cardiac hypertrophy ( J:111573 )

• cardiac hypertrophy is not enhanced above that observed in Tg(Myh6-Mef2c)2Jmol single transgenic animals

Genotype
MGI:3851787

tg2

• Allelic Composition: Tg(Myh6-Mef2c)2Jmol/0
• Genetic Background: involves: FVB

cardiovascular system

abnormal heart atrium morphology ( J:111573 )

• mice show large atrial clots

cardiac hypertrophy ( J:111573 )

increased heart ventricle size ( J:111573 )

• ventricle weight (normalized to body weight) increases following the decrease in fractional shortening and ventricle dilation

dilated heart ventricle ( J:111573 )

dilated heart left ventricle ( J:111573 )

• mice show progressive ventricular chamber dilation

dilated cardiomyopathy ( J:111573 )

• when subjected to transverse aortic constriction, mice die after 1-3 days due to pressure overload stimulation

decreased cardiac muscle contractility ( J:111573 )

• mice show a progressive decrease in fractional shortening

muscle

dilated cardiomyopathy ( J:111573 )

• when subjected to transverse aortic constriction, mice die after 1-3 days due to pressure overload stimulation

decreased cardiac muscle contractility ( J:111573 )

• mice show a progressive decrease in fractional shortening

growth/size/body

cardiac hypertrophy ( J:111573 )