Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Map2k7)1Jmol
• Allele Name: transgene insertion 1, Jeffery D Molkentin
• Allele ID: MGI:3851578
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Map2k7)1Jmol/0	involves: FVB/N	MGI:3851983

Genotype
MGI:3851983

tg1

• Allelic Composition: Tg(Myh6-Map2k7)1Jmol/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:102152 )

• at 7 weeks, mice have a 10-15% increase in normalized heart weight

cardiac hypertrophy ( J:102152 )

• slight degree observed at 7 weeks through 6 months of age

abnormal cardiac muscle contractility ( J:102152 )

• mice are slightly hyperfunctional in systole, likely due to the small degree of hypertrophy

decreased cardiomyocyte apoptosis ( J:102152 )

• mice have lower levels of apoptotic cells in infarcted area after I-R injury

decreased myocardial infarct size ( J:102152 )

• after ischemia-reperfusion injury, mice have smaller infarctions compared with controls

muscle

abnormal cardiac muscle contractility ( J:102152 )

• mice are slightly hyperfunctional in systole, likely due to the small degree of hypertrophy

decreased cardiomyocyte apoptosis ( J:102152 )

• mice have lower levels of apoptotic cells in infarcted area after I-R injury

homeostasis/metabolism

decreased myocardial infarct size ( J:102152 )

• after ischemia-reperfusion injury, mice have smaller infarctions compared with controls

cellular

decreased cardiomyocyte apoptosis ( J:102152 )

• mice have lower levels of apoptotic cells in infarcted area after I-R injury

growth/size/body

increased heart weight ( J:102152 )

• at 7 weeks, mice have a 10-15% increase in normalized heart weight

cardiac hypertrophy ( J:102152 )

• slight degree observed at 7 weeks through 6 months of age