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Allele Symbol Allele Name Allele ID |
Tg(Myh6-Mapk14*)1Jmol transgene insertion 1, Jeffery D Molkentin MGI:3851575 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at 2 months, mice show complete rescue in hypertrophic growth seen in Tg(Myh6-Mapk14*)1Jmol animals
• rescue of the chamber enlargement and reduced fractional shortening is also observed
• interstitial cell fibrosis is significantly attenuated compare with Tg(Myh6-Mapk14*)1Jmol mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die by 8 months from lethal cardiomyopathy
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• myocyte cross-sectional area is increased significantly by 4 months of age
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• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls
• before 2 months of age, mice exhibit concentric hypertrophic remodeling
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• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thicknesses suggesting cardiomyopathy
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• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy
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• insterstitial cell fibrosis is observed by 4 months of age
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• by 4 months, fractional shortening is significantly reduced
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• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age
• diastolic dysfunction is reduced by 4 months of age
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• myocyte cross-sectional area is increased significantly by 4 months of age
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• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy
|
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• by 4 months, fractional shortening is significantly reduced
|
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• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age
• diastolic dysfunction is reduced by 4 months of age
|
|
• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls
• before 2 months of age, mice exhibit concentric hypertrophic remodeling
|
|
• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy
|
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• insterstitial cell fibrosis is observed by 4 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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