Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Map2k3*)1Jmol
• Allele Name: transgene insertion 1, Jeffery D Molkentin
• Allele ID: MGI:3851571
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Map2k3*)1Jmol/0	FVB-Tg(Myh6-Map2k3*)1Jmol	MGI:3851719

Genotype
MGI:3851719

tg1

• Allelic Composition: Tg(Myh6-Map2k3*)1Jmol/0
• Genetic Background: FVB-Tg(Myh6-Map2k3*)1Jmol

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:83547 )

• most die by 8 months resulting from lethal cardiomyopathy

cardiovascular system

increased myocardial fiber size ( J:83547 )

• myocyte cross-sectional area is increased significantly by 4 months of age

cardiac hypertrophy ( J:83547 )

• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls

• before 2 months of age, mice exhibit concentric hypertrophic remodeling

• at 2 months, mice show greater than 2-fold increase in heart-to-body weight ratio compared to sham controls induced by 14 days of aortic banding; mice also display a significantly greater percent increase in heart-to-body weight versus controls after 14 days of infusion of angiotensin II, isoproterenol, or phenylephrine

abnormal heart left ventricle morphology ( J:83547 )

• thinning of left ventricular free wall and septum are observed at later time points

heart left ventricle hypertrophy ( J:83547 )

• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy

cardiac interstitial fibrosis ( J:83547 )

• insterstitial cell fibrosis is observed by 4 months of age

decreased cardiac muscle contractility ( J:83547 )

• by 4 months, fractional shortening is significantly reduced

decreased ventricle muscle contractility ( J:83547 )

• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age

cardiomyopathy ( J:83547 )

muscle

increased myocardial fiber size ( J:83547 )

• myocyte cross-sectional area is increased significantly by 4 months of age

heart left ventricle hypertrophy ( J:83547 )

• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy

decreased cardiac muscle contractility ( J:83547 )

• by 4 months, fractional shortening is significantly reduced

decreased ventricle muscle contractility ( J:83547 )

• left ventricular pressure gradient versus time (systolic function) is significantly reduced by 4 months of age

cardiomyopathy ( J:83547 )

growth/size/body

cardiac hypertrophy ( J:83547 )

• at 2 months, mice show significant increase in heart-to-body weight ratios that increase with age compared to controls

• before 2 months of age, mice exhibit concentric hypertrophic remodeling

• at 2 months, mice show greater than 2-fold increase in heart-to-body weight ratio compared to sham controls induced by 14 days of aortic banding; mice also display a significantly greater percent increase in heart-to-body weight versus controls after 14 days of infusion of angiotensin II, isoproterenol, or phenylephrine

heart left ventricle hypertrophy ( J:83547 )

• end-diastolic and end-systolic dimensions are significantly increased, with unchanged or decreased wall thickness suggesting cardiomyopathy

cellular

cardiac interstitial fibrosis ( J:83547 )

• insterstitial cell fibrosis is observed by 4 months of age