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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arb2a+
wild type
MGI:3851552
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Arb2aTg(Tyr)TpNpln/Arb2a+ involves: FVB/N MGI:7429208
cx2
 		Chd7Gt(S20-7E1)Sor/Chd7+
Arb2aTg(Tyr)TpNpln/Arb2a+ 		involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:7429212


Genotype
MGI:7429208
ht1
Allelic
Composition		 Arb2aTg(Tyr)TpNpln/Arb2a+
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arb2aTg(Tyr)TpNpln mutation (0 available); any Arb2a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
head spot ( J:260599 )
• white spot is seen on the head

pigmentation
head spot ( J:260599 )
• white spot is seen on the head




Genotype
MGI:7429212
cx2
Allelic
Composition		 Chd7Gt(S20-7E1)Sor/Chd7+
Arb2aTg(Tyr)TpNpln/Arb2a+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arb2aTg(Tyr)TpNpln mutation (0 available); any Arb2a mutation (30 available)
Chd7Gt(S20-7E1)Sor mutation (1 available); any Chd7 mutation (134 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:260599 )
• mice exhibit a higher frequency of premature postnatal death
prenatal lethality, incomplete penetrance ( J:260599 )
• lower than expected number of mice at birth

growth/size/body
decreased body size ( J:260599 )
• mice are smaller at weaning age than wild-type mice or either single heterozygote

behavior/neurological

reproductive system
sex reversal ( J:260599 )
• mice exhibit a higher frequency of male-to-female sex reversal

vision/eye
abnormal optic fissure closure ( J:260599 )
• E12.5 eyes show a wider choroidal fissure than in either single heterozygote
retina coloboma ( J:260599 )
• coloboma is much more severe than in single heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory