Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbstm1Unc mutation
(3 available);
any
Cbs mutation
(40 available)
Tg(Mt1-CBS)25Waku mutation
(0 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Cbstm1Unc mutation
(3 available);
any
Cbs mutation
(40 available)
Tg(Mt1-CBS)25Waku mutation
(0 available)
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cardiovascular system
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• zinc-induced mice fed a high-fat diet exhibit increased atherosclerotic lesions compared to controls
• zinc-induced mice fed a high-fat diet exhibit enhanced Ly-6C monocyte/macrophage accumulation in atherosclerotic lesions
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growth/size/body
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• zinc-induced mice fed a high fat diet develop severe hyperhomocysteinemia associated with a 15.6% reduction in body weight
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hematopoietic system
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• increase in monocyte population in blood, spleen, and bone marrow of 15 months old zinc-induced mice fed a regular diet
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• zinc-induced mice fed a regular diet with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6Chi and CD11b+Ly-6Cmid inflammatory monocyte subsets
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homeostasis/metabolism
immune system
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• increase in monocyte population in blood, spleen, and bone marrow of 15 months old zinc-induced mice fed a regular diet
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• zinc-induced mice fed a regular diet with severe hyperhomocysteinemia exhibit elevated CD11b+Ly-6Chi and CD11b+Ly-6Cmid inflammatory monocyte subsets
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• high-fat diet fed zinc-induced mice show increased plasma levels of the proinflammatory cytokine TNF-alpha and the chemotactic factor MCP-1
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