Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx4tm1Bros mutation
(0 available);
any
Cplx4 mutation
(16 available)
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vision/eye
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N |
• despite eye electrophysiological abnormalities, no defects in retinal morphology are detected
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• slight but significant reduction in a-wave amplitude at medium light intensities
• slight increase in peak frequency of oscillatory potentials
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• slight but significant reduction in b-wave amplitude at the lowest light intensities tested
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cplx3tm1Bros mutation
(0 available);
any
Cplx3 mutation
(7 available)
Cplx4tm1Bros mutation
(0 available);
any
Cplx4 mutation
(16 available)
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vision/eye
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• many photoreceptor ribbon synapse complexes are disintegrated
• in adults photoreceptor terminals containing spherical free floating ribbons are seen
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• significant reduction in b-wave amplitudes and prolongation of b-wave implicit times at all light intensities
• slight increase in a-wave amplitudes and prolongation of a-wave implicit times at medium light intensities
• peak power but not peak frequency of oscillatory potentials is reduced
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• mice take more time to reach the visible platform in a cued platform test in the Morris water maze; however, mice show a normal learning curve in this test and normal motor function indicating the delay is due to impaired vision
• in contrast, performance in a visual cliff test is similar to controls
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nervous system
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• many photoreceptor ribbon synapse complexes are disintegrated
• in adults photoreceptor terminals containing spherical free floating ribbons are seen
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Analysis Tools