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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mdm4tm1.1Wahl
targeted mutation 1.1, Goeff Wahl
MGI:3850668
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mdm4tm1.1Wahl/Mdm4tm1.1Wahl involves: 129S/Sv * C57BL/6 MGI:3850670
cx2
 		Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl 		involves: 129S/Sv * C57BL/6 MGI:3850671


Genotype
MGI:3850670
hm1
Allelic
Composition		 Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm1.1Wahl mutation (0 available); any Mdm4 mutation (191 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased mortality induced by ionizing radiation ( J:150341 )
• only 60% of mice die following exposure to radiation that kills all wild-type mice

hematopoietic system
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells
increased erythrocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate anemia compared to the severe anemia observed in similarly treated mice
thrombocytosis ( J:150341 )
• following irradiation, mice exhibit only moderate thrombocytopenia compared to the severe thrombocytopenia observed in similarly treated mice
increased leukocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate leucopenia compared to the severe leucopenia observed in similarly treated mice

cellular
decreased cellular sensitivity to gamma-irradiation ( J:150341 )
• mouse embryonic fibroblasts exhibit resistance to gamma-radiation cell cycle arrest unlike wild-type cells
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells

neoplasm
neoplasm ( J:150341 )
N
• mice exhibit no obvious tumor predisposition

immune system
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells
increased leukocyte cell number ( J:150341 )
• following irradiation, mice exhibit only moderate leucopenia compared to the severe leucopenia observed in similarly treated mice

homeostasis/metabolism
decreased mortality induced by ionizing radiation ( J:150341 )
• only 60% of mice die following exposure to radiation that kills all wild-type mice

endocrine/exocrine glands
decreased thymocyte apoptosis ( J:150341 )
• irradiation-exposed thymic cells exhibit decreased apoptosis compared to similarly treated wild-type cells




Genotype
MGI:3850671
cx2
Allelic
Composition		 Ightm1(Myc)Janz/Igh+
Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic
Background		 involves: 129S/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1(Myc)Janz mutation (2 available); any Igh mutation (43 available)
Mdm4tm1.1Wahl mutation (0 available); any Mdm4 mutation (191 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:150341 )
• mice exhibit increased premature lethality compared with Ightm1Janz heterozygotes

immune system

neoplasm
increased lymphoma incidence ( J:150341 )
• lymphomagenesis is accelerated compared to in Ightm1Janz heterozygotes

hematopoietic system

liver/biliary system

cellular

growth/size/body
enlarged liver ( J:150341 )
enlarged spleen ( J:150341 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory