Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1Low mutation
(1 available);
any
Drd2 mutation
(70 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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nervous system
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N |
• astrocytes exhibit normalized RNA expression of pro-inflammatory mediators compared to in Drd2tm1Low homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation
(2 available);
any
Gfap mutation
(47 available)
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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mortality/aging
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N |
• all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age
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nervous system
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• Rosenthal fibers are observed, but numbers are significantly less than in Gfaptm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(9Hspb2-Cryab)1Wawr mutation
(0 available);
any
Del(9Hspb2-Cryab)1Wawr mutation
(0 available)
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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mortality/aging
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• majority of animals (about 90%) survive to 3 months of age
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growth/size/body
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N |
• mice show significantly increased body weights at 6 weeks and three months relative to Tg(GFAP)10Mes and Tg(GFAP)10/Tg(GFAP-Cryab)141.6Mes Cryab-null animals; weights are comparable to wild-type
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nervous system
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• Rosenthal fibers which outline astrocytic processes are present in mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation
(2 available);
any
Gfap mutation
(47 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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cellular
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• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfaptm2Hgmn/+/+ mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP)10Mes mutation
(0 available)
Tg(GFAP-CRYAB)141.6Mes mutation
(1 available)
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cellular
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• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfaptm2Hgmn/+/+ mice
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Analysis Tools
