All Phenotypes Efnb1<tm3.2Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Efnb1^tm3.2Sor
targeted mutation 3.2, Philippe Soriano
MGI:3850116

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efnb1^tm3.2Sor/Efnb1^tm3.2Sor	involves: 129S4/SvJaeSor	MGI:3850136
hm2	Efnb1^tm3.2Sor/Efnb1^tm3.2Sor	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:3850137
ht3	Efnb1^tm3.2Sor/Efnb1⁺	involves: 129S4/SvJaeSor	MGI:3850135
ht4	Efnb1^tm3.2Sor/Efnb1⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:3850139
ot5	Efnb1^tm3.2Sor/Y	involves: 129S4/SvJaeSor	MGI:3850134
ot6	Efnb1^tm3.2Sor/Y	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:3850138

Allelic Composition	Efnb1^tm3.2Sor/Efnb1^tm3.2Sor
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corpus callosum morphology ( J:150043 )

• at E17.5, corpus callosum axons fail to cross the midline and accumulate ipsilateral bundles unlike in wild-type mice

• the corpus callosum appear defasciculated and wandering axon fibers are visible unlike in wild-type mice

absent corpus callosum ( J:150043 )

• Background Sensitivity: in 8 of 10 mice unlike mice on a mixed 129S4 and C57BL/6 background

skeleton

skeleton phenotype ( J:150043 )

N	• mice exhibit normal skeletal development

Allelic Composition	Efnb1^tm3.2Sor/Efnb1^tm3.2Sor
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:150043 )

N	• mice exhibit normal corpus callosum development unlike on a 129S4 background

Allelic Composition	Efnb1^tm3.2Sor/Efnb1⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent corpus callosum ( J:150043 )

• in 2 of 2 mice

skeleton

skeleton phenotype ( J:150043 )

N	• mice exhibit normal skeletal development

Allelic Composition	Efnb1^tm3.2Sor/Efnb1⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:150043 )

N	• mice exhibit normal brain morphology

Allelic Composition	Efnb1^tm3.2Sor/Y
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal corpus callosum morphology ( J:150043 )

• at E17.5, corpus callosum axons fail to cross the midline and accumulate ipsilateral bundles unlike in wild-type mice

• the corpus callosum appear defasciculated and wandering axon fibers are visible unlike in wild-type mice

absent corpus callosum ( J:150043 )

• Background Sensitivity: 8 of 10 mice lack a corpus callosum unlike mice with a mixed 129S4 and C57BL/6 background

skeleton

skeleton phenotype ( J:150043 )

Allelic Composition	Efnb1^tm3.2Sor/Y
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1^tm3.2Sor mutation (0 available); any Efnb1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:150043 )

N	• mice exhibit normal corpus callosum development unlike on a 129S4 background

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