Phenotypes associated with this allele

• Allele Symbol: m128-7Tpo
• Allele Name: mutation 128-7, Timothy P O'Brien
• Allele ID: MGI:3849693
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	m128-7Tpo/m128-7Tpo	involves: C57BL/6J * SSL/LeJ	MGI:3849719
cx2	Ednrb^s-24Pub/Ednrb^+ m128-7Tpo/m128-7Tpo^+	involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ	MGI:3849718

Genotype
MGI:3849719

hm1

• Allelic Composition: m128-7Tpo/m128-7Tpo
• Genetic Background: involves: C57BL/6J * SSL/LeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:149893 )

• mice exhibit the same lethality as observed in m128-7Tpo Ednrb^s-24Pub heterozygotes

Genotype
MGI:3849718

cx2

• Allelic Composition: Ednrb^s-24Pub/Ednrb⁺; m128-7Tpo/m128-7Tpo⁺
• Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

Developmental defects of Ednrb^s-24Pub/Ednrb⁺ m128-7Tpo/m128-7Tpo⁺ embryos

mortality/aging

embryonic lethality, complete penetrance ( J:149893 )

• mice die mid-gestation

embryo

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

incomplete embryo turning ( J:149893 )

• at E10.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:149893 )

• at E10.5, yolk sacs lack mature blood vessels unlike in wild-type mice

abnormal direction of heart looping ( J:149893 )

• randomized

hemopericardium ( J:149893 )

• at E10.5

enlarged pericardium ( J:149893 )

• at E10.5

craniofacial

abnormal pharyngeal arch morphology ( J:149893 )

• at E10.5

homeostasis/metabolism

hemopericardium ( J:149893 )

• at E10.5

growth/size/body

abnormal head morphology ( J:149893 )

• at E10.5