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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Rr141-cre)1Ksec
transgene insertion 1, Katheryn S E Cheah
MGI:3849597
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:7451331
cn2
 		Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA MGI:7451336
cn3
 		Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * C57BL/6 * CBA MGI:7451326
cn4
 		Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0 		involves: 129S/SvEv * C57BL/6 * CBA MGI:7451340


Genotype
MGI:7451331
cn1
Allelic
Composition		 Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm2Crm mutation (1 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:332093 )
N
• normal cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451336
cn2
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm2Crm/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm2Crm mutation (1 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• larger cross-section of basal cochlear lumen in E15.5 embryos




Genotype
MGI:7451326
cn3
Allelic
Composition		 Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm1.1Ksec mutation (0 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired righting response ( J:332093 )
• impaired contact righting starting before weaning
abnormal placing response ( J:332093 )
• onset before weaning
head tilt ( J:332093 )
• onset before weaning
head tossing ( J:332093 )
• onset before weaning
hyperactivity ( J:332093 )
• onset before weaning
circling ( J:332093 )
• onset before weaning

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:332093 )
N
• normal otic vesicles in E9.5embryos
• normal scala vestibuli morphology in adult mice
• normal hair cell and stereocilia arrangement in organ of Corti at age P4
• normal apoptosis rates of cochlea epithelial cells in E14.5 e
dilated cochlea ( J:332093 )
• ~3.2x larger cross-section of basal cochlear lumen in E15.5 embryos
dilated scala media ( J:332093 )
• doubled in size in adult mice
• dilation of cochlear duct starting in E15 em
small scala tympani ( J:332093 )
• ~30% smaller in adult mice
dilated endolymphatic duct ( J:332093 )
• in adult mice and E16.5 embryos
nonsyndromic hearing impairment ( J:332093 )
• hearing deficit from 40 to 80 dB starting before weaning




Genotype
MGI:7451340
cn4
Allelic
Composition		 Sox10tm1Ngan/Sox10+
Sox9tm1.1Ksec/Sox9+
Tg(Rr141-cre)1Ksec/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm1Ngan mutation (0 available); any Sox10 mutation (33 available)
Sox9tm1.1Ksec mutation (0 available); any Sox9 mutation (32 available)
Tg(Rr141-cre)1Ksec mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
dilated cochlea ( J:332093 )
• ~2.7x larger cross-section of basal cochlear lumen in E15.5 embryos




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory