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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2axtm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:3849331
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		H2axtm1Nus/H2axtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0 		involves: 129S6/SvEvTac * FVB/N MGI:3849332


Genotype
MGI:3849332
cn1
Allelic
Composition		 H2axtm1Nus/H2axtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2axtm1Nus mutation (1 available); any H2ax mutation (7 available)
H2axtm2.1Fwa mutation (0 available); any H2ax mutation (7 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
retina neovascularization ( J:149487 )
• hypoxia induced retinal neovascularization is decreased compared to controls
abnormal tumor vascularization ( J:149487 )
• vascularization of implanted tumors is reduced compared to controls

neoplasm
abnormal tumor vascularization ( J:149487 )
• vascularization of implanted tumors is reduced compared to controls
decreased tumor growth/size ( J:149487 )
• growth of implanted Lewis lung carcinomas is reduced compared to controls

vision/eye
retina neovascularization ( J:149487 )
• hypoxia induced retinal neovascularization is decreased compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory