About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2axtm2.1Fwa
targeted mutation 2.1, Frederick W Alt
MGI:3849331
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		H2axtm1Nus/H2axtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0 		involves: 129S6/SvEvTac * FVB/N MGI:3849332


Genotype
MGI:3849332
cn1
Allelic
Composition		 H2axtm1Nus/H2axtm2.1Fwa
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2axtm1Nus mutation (1 available); any H2ax mutation (6 available)
H2axtm2.1Fwa mutation (0 available); any H2ax mutation (6 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
retina neovascularization ( J:149487 )
• hypoxia induced retinal neovascularization is decreased compared to controls
abnormal tumor vascularization ( J:149487 )
• vascularization of implanted tumors is reduced compared to controls

neoplasm
abnormal tumor vascularization ( J:149487 )
• vascularization of implanted tumors is reduced compared to controls
decreased tumor growth/size ( J:149487 )
• growth of implanted Lewis lung carcinomas is reduced compared to controls

vision/eye
retina neovascularization ( J:149487 )
• hypoxia induced retinal neovascularization is decreased compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory