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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim21tm1Hm
targeted mutation 1, Herbert Morse III
MGI:3849316
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim21tm1Hm/Trim21tm1Hm C57BL/6-Trim21tm1Hm/J MGI:7627124
hm2
 		Trim21tm1Hm/Trim21tm1Hm involves: C57BL/6 MGI:3849319


Genotype
MGI:7627124
hm1
Allelic
Composition		 Trim21tm1Hm/Trim21tm1Hm
Genetic
Background		 C57BL/6-Trim21tm1Hm/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim21tm1Hm mutation (1 available); any Trim21 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased salivation ( J:306292 )
• increased by ~23%

cardiovascular system
cardiovascular system phenotype ( J:306292 )
N
• heart rate is similar to controls

endocrine/exocrine glands
increased salivation ( J:306292 )
• increased by ~23%

homeostasis/metabolism
increased salivation ( J:306292 )
• increased by ~23%




Genotype
MGI:3849319
hm2
Allelic
Composition		 Trim21tm1Hm/Trim21tm1Hm
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim21tm1Hm mutation (1 available); any Trim21 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:149298 )
• 25% less CD11c+ dendritic cells are generated in vitro from mutant bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory