Phenotypes associated with this allele

• Allele Symbol: Tg(Foxp3-HBEGF/EGFP)23.2Spar
• Allele Name: transgene insertion 23.2, Tim Sparwasser
• Allele ID: MGI:3849080
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Foxp3-HBEGF/EGFP)23.2Spar/0	involves: C57BL/6NCrl	MGI:4429143

Genotype
MGI:4429143

tg1

• Allelic Composition: Tg(Foxp3-HBEGF/EGFP)23.2Spar/0
• Genetic Background: involves: C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:125295 )

N • mice exhibit normal numbers and frequencies of CD25+CD4+ T regulatory cells

enlarged spleen ( J:125295 )

• following diphtheria toxin treatment of neonates

decreased regulatory T cell number ( J:125295 )

• following diphtheria toxin treatment, CD4+ T regulatory cells are decreased in adult and neonates compared to in similarly treated wild-type mice

• however, T regulatory cell numbers rebound after cessation of diphtheria treatment in adult mice but not neonates

increased spleen red pulp amount ( J:125295 )

• following diphtheria toxin treatment of neonates

increased spleen white pulp amount ( J:125295 )

• following diphtheria toxin treatment of neonates

enlarged lymph nodes ( J:125295 )

• following diphtheria toxin treatment of neonates

lymph node hyperplasia ( J:125295 )

• following diphtheria toxin treatment of neonates

increased inflammatory response ( J:125295 )

• diphtheria toxin treated-neonates exhibit massive inflammatory infiltrate in various organs that resembles the phenotype of Foxp3^sf hemizygotes

insulitis ( J:125295 )

• following diphtheria toxin treatment of neonates, mice exhibit insulitis and portal aggregates unlike similarly treated wild-type mice

increased susceptibility to type IV hypersensitivity reaction ( J:125295 )

• following diphtheria toxin treatment, adult mice exhibit an enhanced and prolonged delayed-type hypersensitivity response compared with similarly treated wild-type mice

lung inflammation ( J:125295 )

• following diphtheria toxin treatment of neonates, mice exhibit peribronchial and perivascular infiltrated unlike similarly treated wild-type mice

skin inflammation ( J:125295 )

• following diphtheria toxin treatment of neonates, the skin overlying the hyaline cartilage of the ear is thickened with epidermal hyperplasia and a dense lymphocyte infiltrate unlike in similarly treated wild-type mice

endocrine/exocrine glands

insulitis ( J:125295 )

• following diphtheria toxin treatment of neonates, mice exhibit insulitis and portal aggregates unlike similarly treated wild-type mice

respiratory system

lung inflammation ( J:125295 )

• following diphtheria toxin treatment of neonates, mice exhibit peribronchial and perivascular infiltrated unlike similarly treated wild-type mice

abnormal pulmonary alveolus morphology ( J:125295 )

• following diphtheria toxin treatment of neonates, alveoli are delicate and have thin walls compared to in similarly treated wild-type mice

hematopoietic system

enlarged spleen ( J:125295 )

• following diphtheria toxin treatment of neonates

decreased regulatory T cell number ( J:125295 )

• following diphtheria toxin treatment, CD4+ T regulatory cells are decreased in adult and neonates compared to in similarly treated wild-type mice

• however, T regulatory cell numbers rebound after cessation of diphtheria treatment in adult mice but not neonates

increased spleen red pulp amount ( J:125295 )

• following diphtheria toxin treatment of neonates

increased spleen white pulp amount ( J:125295 )

• following diphtheria toxin treatment of neonates

integument

skin inflammation ( J:125295 )

• following diphtheria toxin treatment of neonates, the skin overlying the hyaline cartilage of the ear is thickened with epidermal hyperplasia and a dense lymphocyte infiltrate unlike in similarly treated wild-type mice

epidermal hyperplasia ( J:125295 )

• following diphtheria toxin treatment of neonates, the skin overlying the hyaline cartilage of the ear is thickened with epidermal hyperplasia and a dense lymphocyte infiltrate unlike in similarly treated wild-type mice

growth/size/body

enlarged spleen ( J:125295 )

• following diphtheria toxin treatment of neonates