Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
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limbs/digits/tail
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• 12 of 17 mice exhibit preaxial polydactyly of often only one extra digit
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1.1Xsun mutation
(2 available);
any
Etv5 mutation
(270 available)
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
Tg(T-cre)1Lwd mutation
(1 available)
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mortality/aging
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• mice die shortly after birth due to internal organ defects
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limbs/digits/tail
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• limb buds exhibit reduced cell death compared to in wild-type mice
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• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
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• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal
• however, forelimbs are normal
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embryo
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• limb buds exhibit reduced cell death compared to in wild-type mice
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skeleton
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• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1.1Xsun mutation
(2 available);
any
Etv5 mutation
(270 available)
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
Tg(T-cre)1Lwd mutation
(1 available)
|
|
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation
(0 available);
any
Etv4 mutation
(40 available)
Etv5tm1.2Xsun mutation
(0 available);
any
Etv5 mutation
(270 available)
|
|
|
mortality/aging
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• mice die prior to limb bud initiation
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