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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Etv5tm1.1Xsun
targeted mutation 1.1, Xin Sun
MGI:3849047
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849054
cn2
 		Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849055


Genotype
MGI:3849054
cn1
Allelic
Composition		 Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (271 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:149477 )
• mice die shortly after birth due to internal organ defects

limbs/digits/tail
abnormal limb bud morphology ( J:149477 )
• limb buds exhibit reduced cell death compared to in wild-type mice
polyphalangy ( J:149477 )
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
preaxial polydactyly ( J:149477 )
• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal
• however, forelimbs are normal

embryo
abnormal limb bud morphology ( J:149477 )
• limb buds exhibit reduced cell death compared to in wild-type mice

skeleton
polyphalangy ( J:149477 )
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice




Genotype
MGI:3849055
cn2
Allelic
Composition		 Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (41 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (271 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (271 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:149477 )
• in 6 of 8 mice




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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory