About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Etv5tm1.1Xsun
targeted mutation 1.1, Xin Sun
MGI:3849047
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849054
cn2
 		Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL MGI:3849055


Genotype
MGI:3849054
cn1
Allelic
Composition		 Etv4tm1Arbr/Etv4tm1Arbr
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (270 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:149477 )
• mice die shortly after birth due to internal organ defects

limbs/digits/tail
abnormal limb bud morphology ( J:149477 )
• limb buds exhibit reduced cell death compared to in wild-type mice
polyphalangy ( J:149477 )
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice
preaxial polydactyly ( J:149477 )
• mice exhibit preaxial polydactyly in the hindlimbs with one or two extra digits the majority of which are triphalangeal
• however, forelimbs are normal

embryo
abnormal limb bud morphology ( J:149477 )
• limb buds exhibit reduced cell death compared to in wild-type mice

skeleton
polyphalangy ( J:149477 )
• 50% of mice have a digit 1 with three phalanges unlike in wild-type mice




Genotype
MGI:3849055
cn2
Allelic
Composition		 Etv4tm1Arbr/Etv4+
Etv5tm1.1Xsun/Etv5tm1.2Xsun
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv4tm1Arbr mutation (0 available); any Etv4 mutation (40 available)
Etv5tm1.1Xsun mutation (2 available); any Etv5 mutation (270 available)
Etv5tm1.2Xsun mutation (0 available); any Etv5 mutation (270 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:149477 )
• in 6 of 8 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory