Analysis Tools
immune system
|
• mice show faster progression of islet inflammation with IDDM that that observed in NOD controls
• at 3 weeks, transgenic mice have lower insulitis scores than controls, but at 6 weeks, insulitis is much more severe
• lesions contain more CD4+ and fewer CD8- T cells
|
|
• transgenic mice develop insulin-dependent diabetes mellitus (IDDM) earlier than NOD controls
• transgenic males show an increased incidence of IDDM versus NOD male controls
|
endocrine/exocrine glands
|
• mice show faster progression of islet inflammation with IDDM that that observed in NOD controls
• at 3 weeks, transgenic mice have lower insulitis scores than controls, but at 6 weeks, insulitis is much more severe
• lesions contain more CD4+ and fewer CD8- T cells
|
